Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

@article{Thomas2009GeneticVI,
  title={Genetic variation in IL28B and spontaneous clearance of hepatitis C virus},
  author={David L. Thomas and Chloe L. Thio and Maureen P. Martin and Ying Qi and Dongliang Ge and Colm O'huigin and Judith R. Kidd and Kenneth K. Kidd and Salim I. Khakoo and Graeme J Alexander and James J. Goedert and Gregory D Kirk and Sharyne M. Donfield and Hugo R. Rosen and Leslie H. Tobler and Michael P. Busch and John McHutchison and David B. Goldstein and Mary N. Carrington},
  journal={Nature},
  year={2009},
  volume={461},
  pages={798 - 801}
}
Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million worldwide. Most (70–80%) HCV infections persist and about 30% of individuals with persistent infection develop chronic liver disease, including cirrhosis and hepatocellular carcinoma. Epidemiological, viral and host factors have been associated with the differences in HCV clearance or persistence, and studies… 
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IL28B polymorphism and genetic biomarkers of viral clearance in hepatitis C virus infection.
TLDR
A association between genetic variation in the region of the IL28B gene and treatment outcome in HCV-1 patients and patients who carry the good response variant are two- to three-fold more likely to be cured.
Hepatitis C virus spontaneous clearance: immunology and genetic variance.
TLDR
Findings of different studies on host immune responses after HCV infection and the association between cytokine gene polymorphisms and the likelihood of HCV clearance are summarized.
The control of immune responses in chronic hepatitis C virus infection
TLDR
The association of IFNL4 polymorphisms with immune response in the liver in patients with chronic HCV infection and the impact of several genetic polymorphisms on the severity of chronic hepatitis C was investigated.
IL28B and the control of hepatitis C virus infection.
TLDR
The genetic studies that uncovered the association between IL28B and HCV clearance, the biology of IFN-λ3, the clinical implications of the genetic association, and areas of future research are reviewed.
[The function and application of the IL28B gene in HCV infection and treatment].
TLDR
The results showed that single nucleotide polymorphisms of the IL28B gene, which encodes protein IFN-lambda3, are associated with viral clearance and treatment effectiveness of HCV patients who were cured by PEG-IFNalpha combined with ribavirin (RBV).
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.
TLDR
The association of the IL28B locus with natural and treatment-associated control of HCV indicates the importance of innate immunity and interferon lambda in the pathogenesis ofHCV infection.
Hepatitis C Virus Genetic Variability, Human Immune Response, and Genome Polymorphisms: Which Is the Interplay?
TLDR
This review summarizes the data on HCV diversity and the current state of knowledge about the contributions of antibodies, T cells, and host genetic polymorphism in driving HCV evolution in vivo.
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