Corpus ID: 73668052

Genetic variation in FOXO 3 is associated with reductions in inflammation and disease activity in inflammatory polyarthritis

@inproceedings{Viatte2016GeneticVI,
  title={Genetic variation in FOXO 3 is associated with reductions in inflammation and disease activity in inflammatory polyarthritis},
  author={Sebastien Viatte and James C. Lee and Bo Fu and Marion Esp{\'e}li and Mark Lunt and Jack and N Wolf and Lizbeth Wheeler and John A Reynolds and Madhura Castelino and D{\'e}borah and Peter Symmons and Paul A. Lyons and Anne Barton and Kenneth G. C. Smith},
  year={2016}
}
Background: Genetic variation in FOXO3 (tagged by rs12212067) has been associated with a milder course of rheumatoid arthritis (RA) and shown to limit monocyte-driven inflammation through a TGFβ1-dependent pathway. This genetic association, however, has not been consistently observed in other RA cohorts. We sought to clarify the contribution of FOXO3 to prognosis in RA by combining detailed analysis of non-radiographic disease severity measures with an in vivo model of arthritis. Methods… Expand

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References

SHOWING 1-10 OF 35 REFERENCES
Does a Genetic Variant in FOXO3A Predict a Milder Course of Rheumatoid Arthritis?
TLDR
The results described by Lee et al are promising, because identification of predictors of interindividual differences in disease outcome is the Holy Grail of personalized medicine and requires replication in independent cohorts. Expand
Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway
TLDR
A shared genetic contribution to prognosis in distinct diseases that operates via a FOXO3-driven pathway modulating inflammatory responses is uncovered. Expand
A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis
TLDR
The data indicate that two loci that confer risk to other autoimmune diseases also affect the severity of joint destruction in RA, and Rs11908352 may influence joint destruction via MMP-9 production. Expand
FOXO3A regulatory polymorphism and susceptibility to severe malaria in Gabonese children
TLDR
The FoxO3A variant rs12212067T>G is associated with increased inflammatory responses to Plasmodium falciparum malaria, indicating a role of the FOXO3-dependent pathway in malaria. Expand
Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis
TLDR
Genetic and functional analyses indicate that SPAG16 influences MMP-3 regulation and protects against joint destruction in autoantibody-positive rheumatoid arthritis. Expand
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.
TLDR
Among patients with RA, the HLA-DRB1 locus, which is associated with disease susceptibility, was also associated with radiological severity, mortality, and treatment response, and replication of these findings in other cohorts is needed. Expand
Genetics and epigenetics of rheumatoid arthritis
TLDR
The major advances in identifying RA genetic susceptibility markers both within and outside of the MHC are reviewed and current knowledge of the role of epigenetics in RA susceptibility is reviewed. Expand
FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue
TLDR
The overexpression of FoxO3a in blood from patients with RA, particularly in PMNs, suggests a potential role for this gene in the pathogenesis of RA through increased survival of blood PMNs. Expand
A7.10 Genetic Variants in the IL-4 and IL-4 Receptor Genes in Association with the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts
TLDR
Genetic variants in IL-4R were identified and independently replicated to associate with progression rate of joint damage in RA. Expand
Allele-dose association of the C5orf30 rs26232 variant with joint damage in rheumatoid arthritis.
TLDR
The variant rs26232, in the first intron of the C5orf30 locus, is associated with the severity of radiologic damage in RA and is independent of established prognostic biomarkers. Expand
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