Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk.

@article{Terry2010GeneticVI,
  title={Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk.},
  author={Kathryn L. Terry and Monica B McGrath and I. -T. Lee and Julie E. Buring and Immaculata De Vivo},
  journal={Gynecologic oncology},
  year={2010},
  volume={117 2},
  pages={255-9}
}
OBJECTIVE Together, steroidogenic acute regulator (StAR) and the cholesterol side chain cleavage enzyme (P450scc), which is encoded by CYP11A1, mediate the initial and rate-limiting step in steroidogenesis. Given the role of estrogens in endometrial carcinogenesis, we hypothesized that genetic variation in StAR and CYP11A1 genes may influence endometrial cancer risk. METHODS We genotyped four CYP11A1 tagging single nucleotide polymorphisms (SNPs) and two StAR SNPs in endometrial cancer case… CONTINUE READING
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