Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia.

@article{Zinkstok2008GeneticVI,
  title={Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia.},
  author={Janneke R. Zinkstok and Nicole Schmitz and Th{\'e}r{\`e}se A M J Van Amelsvoort and Martina Moeton and Frank Baas and Don H. Linszen},
  journal={Genes, brain, and behavior},
  year={2008},
  volume={7 1},
  pages={61-9}
}
Haploinsufficiency of 22q11 genes including catechol-O-methyltransferase (COMT) and proline dehydrogenase (PRODH) may result in structural and functional brain abnormalities and increased vulnerability to schizophrenia as observed in patients with microdeletions of 22q11. Thus, COMT and PRODH could be modifier genes for schizophrenia. We examined association of polymorphisms in COMT and PRODH with brain anatomy in young patients with schizophrenia and schizoaffective disorder. We acquired… CONTINUE READING