Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.

@article{Polisecki2008GeneticVA,
  title={Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.},
  author={Eliana Y Polisecki and Inga Peter and Michele Robertson and Alex D. McMahon and Ian Ford Ford and Christopher J. Packard and James Michael Shepherd and J Wouter Jukema and Gerard Jan Blauw and Rudi G. J. Westendorp and Anton J. M. de Craen and Stella Trompet and Brendan M. Buckley and Michael B. Murphy and Jos{\'e} M. Ordov{\'a}s and Ernst J. Schaefer},
  journal={Atherosclerosis},
  year={2008},
  volume={200 1},
  pages={95-101}
}
Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low-density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk. Our objective was to examine two PCSK9 single nucleotide polymorphisms (SNPs), R46L and E670G, in 5783 elderly participants in Prospective Study of Pravastatin in the Elderly at Risk (PROSPER), of whom 43% had a history of vascular disease at… CONTINUE READING

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