Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.

@article{Polisecki2008GeneticVA,
  title={Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.},
  author={Eliana Y Polisecki and Hind Elias Muallem and Nobuyo N. Maeda and Inga Peter and Michele Robertson and Alex D. McMahon and Ian Ford Ford and Christopher J. Packard and James Michael Shepherd and J Wouter Jukema and Rudi G. J. Westendorp and Anton J. M. de Craen and Brendan M. Buckley and Jos{\'e} M. Ordov{\'a}s and Ernst J. Schaefer},
  journal={Atherosclerosis},
  year={2008},
  volume={200 1},
  pages={109-14}
}
Our purpose was to evaluate associations of single nucleotide polymorphisms (SNPs) at the low density lipoprotein (LDL) receptor (LDLR C44857T, minor allele frequency (MAF) 0.26, and A44964G, MAF 0.25, both in the untranslated region) and HMG-CoA reductase (HMGCR i18 T>G, MAF 0.019) gene loci with baseline lipid values, statin-induced LDL-cholesterol (C) lowering response, and incident coronary heart disease (CHD) and cardiovascular disease (CVD) on trial. Our population consisted of 5804… CONTINUE READING

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