Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1.

@article{berg2013GeneticVA,
  title={Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1.},
  author={Nina {\AA}berg and Sandra Olsson and David N. {\AA}berg and Katarina Jood and Tara M. Stanne and Michael W Nilsson and Christian Blomstrand and Johan Svensson and J{\"o}rgen Isgaard and Christina Jern},
  journal={European journal of endocrinology},
  year={2013},
  volume={169 6},
  pages={759-65}
}
OBJECTIVE In humans, serum IGF1 (s-IGF1) is associated with outcome after ischemic stroke (IS). Therefore variation at the IGF1 locus could also associate with both IS and s-IGF1. We investigated whether genetic variation at the IGF1 locus is associated with i) s-IGF1, ii) IS occurrence, iii) IS severity, and iv) post-stroke outcome. DESIGN/METHODS Patients (n=844; 66% males, mean age 56 years) and community controls (n=668) were included from the Sahlgrenska Academy Study on Ischemic Stroke… CONTINUE READING