Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity.

@article{Gorden2013GeneticVA,
  title={Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity.},
  author={Alexis Gorden and Rongze Yang and Laura M Yerges-Armstrong and Kathleen A. Ryan and Elizabeth K. Speliotes and Ingrid B. Borecki and T. B. Harris and Xin Chu and G Craig Wood and Christopher D. Still and Alan R. Shuldiner and Glenn S. Gerhard},
  journal={Human heredity},
  year={2013},
  volume={75 1},
  pages={34-43}
}
OBJECTIVE Obesity-associated non-alcoholic fatty liver disease (NAFLD) may cause liver dysfunction and failure. In a previously reported genome-wide association meta-analysis, single nucleotide polymorphisms (SNPs) near PNPLA3, NCAN, GCKR, LYPLAL1 and PPP1R3B were associated with NAFLD and with distinctive serum lipid profiles. The present study examined… CONTINUE READING