Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.

@article{Biffi2012GeneticVA,
  title={Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.},
  author={Alessandro Biffi and Joshua M Shulman and Jeremiasz M Jagiella and Lynelle Cortellini and A Ayres and Kristin E Schwab and Devin L Brown and Scott Silliman and Magdy M Selim and Bradford Worrall and James F Meschia and Agnieszka Julia Slowik and Philip L De Jager and Steven A. Greenberg and Julie A Schneider and David A. Bennett and Jonathan Rosand},
  journal={Neurology},
  year={2012},
  volume={78 5},
  pages={334-41}
}
OBJECTIVE Accumulated evidence suggests that a variant within the CR1 gene (single nucleotide polymorphism rs6656401), known to increase risk for Alzheimer disease (AD), influences β-amyloid (Aβ) deposition in brain tissue. Given the biologic overlap between AD and cerebral amyloid angiopathy (CAA), a leading cause of intracerebral hemorrhage (ICH) in elderly individuals, we investigated whether rs6656401 increases the risk of CAA-related ICH and influences vascular Aβ deposition. METHODS We… CONTINUE READING
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