Genetic variation and susceptibility to infection: the red cell and malaria

@article{Weatherall2008GeneticVA,
  title={Genetic variation and susceptibility to infection: the red cell and malaria},
  author={D. Weatherall},
  journal={British Journal of Haematology},
  year={2008},
  volume={141}
}
  • D. Weatherall
  • Published 2008
  • Biology, Medicine
  • British Journal of Haematology
    • There is now convincing evidence that the extremely high frequencies of certain genetic disorders of the red cell involving haemoglobin, the red‐cell membrane, or its metabolic pathways reflect relative resistance to malaria over thousands of years. At least some progress has been made towards an understanding of the cellular mechanisms involved, although much remains to be learnt. As well as the extremely valuable information that this field is providing about how exposure to infection has… CONTINUE READING
    View on Wiley
    onlinelibrary.wiley.com
    109 Citations
    Highly Influencial Citations
    2
    Background Citations
    48

    Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    109 Citations
    Citation Type

    Citation Type

    Red cell polymorphisms and malaria: an evolutionary approach
    • F. Bauduer
    • Biology
    • Bulletins et mémoires de la Société d'anthropologie de Paris
    • 2012
    • 8
    The population genetics and dynamics of the thalassemias.
    • 45
    Population genetics of malaria resistance in humans
    • 182
    • Highly Influenced
    • PDF
    Sickle cell protection from malaria
    • 17
    Recent Insights into the Population Genetics Disorders of Hemoglobin
    Evolution of Genetic Resistance/Susceptibility to Malaria Infection
    • 1
    Mechanisms of genetically-based resistance to malaria.
    • 122
    Resistance to malaria in humans: the impact of strong, recent selection
    • 42
    The relationship between blood groups and disease.
    • 276
    Protective Resistance by Human G6PD Enzyme Deficiency and Hemoglobin Variants Against Malaria and Natural Selection: Further Evidence from Review of New Studies

    References

    SHOWING 1-10 OF 109 REFERENCES
    Red blood cell defects and malaria.
    • T. Williams
    • Biology, Medicine
    • Molecular and biochemical parasitology
    • 2006
    • 95
    • Highly Influential
    Genetic variability in response to infection: malaria and after
    • 72
    • PDF
    Malaria and the red cell.
    • 91
    • PDF
    Malaria and the Red Cell
    • 158
    Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria
    • 265
    How malaria has affected the human genome and what human genetics can teach us about malaria.
    • 894
    • Highly Influential
    • PDF
    An Immune Basis for Malaria Protection by the Sickle Cell Trait
    • 190
    • PDF
    Protective effects of the sickle cell gene against malaria morbidity and mortality
    • 529
    • PDF
    Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state.
    • 87
    • PDF
    A non-sense mutation in Cd36 gene is associated with protection from severe malaria
    • 118