Genetic variation and susceptibility to infection: the red cell and malaria

  title={Genetic variation and susceptibility to infection: the red cell and malaria},
  author={D. Weatherall},
  journal={British Journal of Haematology},
  • D. Weatherall
  • Published 2008
  • Biology, Medicine
  • British Journal of Haematology
  • There is now convincing evidence that the extremely high frequencies of certain genetic disorders of the red cell involving haemoglobin, the red‐cell membrane, or its metabolic pathways reflect relative resistance to malaria over thousands of years. At least some progress has been made towards an understanding of the cellular mechanisms involved, although much remains to be learnt. As well as the extremely valuable information that this field is providing about how exposure to infection has… CONTINUE READING
    111 Citations

    Topics from this paper

    Red cell polymorphisms and malaria: an evolutionary approach
    • F. Bauduer
    • Biology
    • Bulletins et mémoires de la Société d'anthropologie de Paris
    • 2012
    • 8
    The population genetics and dynamics of the thalassemias.
    • 46
    Population genetics of malaria resistance in humans
    • 185
    • Highly Influenced
    • PDF
    Recent Insights into the Population Genetics and Dynamics of the Inherited Disorders of Hemoglobin
    • D. Weatherall
    • Biology, Medicine
    • Mediterranean journal of hematology and infectious diseases
    • 2009
    • 2
    Sickle cell protection from malaria
    • 17
    Mechanisms of genetically-based resistance to malaria.
    • 124
    Resistance to malaria in humans: the impact of strong, recent selection
    • 42
    The relationship between blood groups and disease.
    • 284


    Red blood cell defects and malaria.
    • T. Williams
    • Biology, Medicine
    • Molecular and biochemical parasitology
    • 2006
    • 97
    • Highly Influential
    Genetic variability in response to infection: malaria and after
    • 73
    • PDF
    Malaria and the Red Cell
    • 161
    Malaria and the red cell.
    • 91
    • PDF
    Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria
    • 266
    How malaria has affected the human genome and what human genetics can teach us about malaria.
    • 907
    • Highly Influential
    • PDF
    An Immune Basis for Malaria Protection by the Sickle Cell Trait
    • 193
    • PDF
    Protective effects of the sickle cell gene against malaria morbidity and mortality
    • 534
    • PDF
    A non-sense mutation in Cd36 gene is associated with protection from severe malaria
    • 119