Genetic variation and RNA structure regulate microRNA biogenesis


MiRNA biogenesis is highly regulated at the post-transcriptional level; however, the role of sequence and secondary RNA structure in this process has not been extensively studied. A single G to A substitution present in the terminal loop of pri-mir-30c-1 in breast and gastric cancer patients had been previously described to result in increased levels of… (More)
DOI: 10.1038/ncomms15114


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