Genetic variation: effect on prostate cancer.

  title={Genetic variation: effect on prostate cancer.},
  author={Tristan Sissung and Douglas K. Price and Marzia Del Re and Ariel M. Ley and Elisa Giovannetti and William D. Figg and Romano Danesi},
  journal={Biochimica et biophysica acta},
  volume={1846 2},
The crucial role of androgens in the development of prostate cancer is well established. The aim of this review is to examine the role of constitutional (germline) and tumor-specific (somatic) polymorphisms within important regulatory genes of prostate cancer. These include genes encoding enzymes of the androgen biosynthetic pathway, the androgen receptor gene, genes that encode proteins of the signal transduction pathways that may have a role in disease progression and survival, and genes… CONTINUE READING
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