Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients

@article{Coulthard2011GeneticVW,
  title={Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients},
  author={Lydia R. Coulthard and John C. Taylor and Stephen Eyre and James I. Robinson and Anthony G. Wilson and John Dudley Isaacs and Kimme L. Hyrich and Paul Emery and Anne Barton and Jennifer H. Barrett and Ann W. Morgan and Michael F. McDermott},
  journal={Annals of the Rheumatic Diseases},
  year={2011},
  volume={70},
  pages={103 - 98}
}
Background Rheumatoid arthritis (RA) does not always respond to available treatments, including tumour necrosis factor (TNF) antagonists. A study was undertaken to investigate whether genetic variation within genes, encoding proteins in the p38 signalling network, contributes to the variable response to TNF antagonists. Methods 1102 UK Caucasian patients with RA receiving anti-TNF therapy (infliximab, adalimumab and etanercept) were genotyped for 38 pairwise-tagging single nucleotide… 

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