Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

@article{Moffatt2007GeneticVR,
  title={Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma},
  author={Miriam F Moffatt and Michael Kabesch and Liming Liang and Anna L. Dixon and David Strachan and Simon Heath and Martin Depner and Andrea von Berg and Albrecht Bufe and Ernst Rietschel and Andrea Heinzmann and Burkard Simma and Thomas Frischer and Saffron A. G. Willis-Owen and Kenny C. C. Wong and Thomas Illig and Christian Vogelberg and Stephan Karl Weiland and Erika von Mutius and Gonçalo R. Abecasis and Martin Farrall and Ivo G Gut and G. M. Lathrop and W. O. C. Cookson},
  journal={Nature},
  year={2007},
  volume={448},
  pages={470-473}
}
Asthma is caused by a combination of poorly understood genetic and environmental factors. We have systematically mapped the effects of single nucleotide polymorphisms (SNPs) on the presence of childhood onset asthma by genome-wide association. We characterized more than 317,000 SNPs in DNA from 994 patients with childhood onset asthma and 1,243 non… CONTINUE READING