Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women’s Health Study

@article{RuizNarvez2010GeneticVO,
  title={Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women’s Health Study},
  author={Edward A Ruiz-Narv{\'a}ez and Lynn Rosenberg and Charles N Rotimi and L. Adrienne Cupples and Deborah A. Boggs and Adebowale Adeyemo and Yvette C. Cozier and Lucile L Adams-Campbell and J R Palmer},
  journal={Breast Cancer Research and Treatment},
  year={2010},
  volume={123},
  pages={525-530}
}
Two single nucleotide polymorphisms (SNPs), rs4415084, and rs10941679 on chromosome 5p12 were associated with risk of breast cancer in a recent genome-wide association study (GWAS) of women of European ancestry. Both SNPs are located in a large high-LD region and the causal variant(s) are still unknown. We conducted a nested case–control study in a cohort of African American women to replicate and narrow the region carrying the causal variant(s). We evaluated 14 tagging SNPs in a 98 kb LD block… CONTINUE READING

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Evaluation of 11 breast cancer susceptibility loci in African-American women.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2009
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