Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.

@article{VanderWeele2012GeneticVO,
  title={Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.},
  author={Tyler J. VanderWeele and Kofi Asomaning and Eric J Tchetgen Tchetgen and Younghun Han and Margaret R. Spitz and Sanjay Shete and Xifeng Wu and Val{\'e}rie Gaborieau and Ying Wang and John McLaughlin and Rayjean J Hung and Paul Brennan and Christopher I. Amos and David C. Christiani and Xihong Lin},
  journal={American journal of epidemiology},
  year={2012},
  volume={175 10},
  pages={
          1013-20
        }
}
Genome-wide association studies have identified variants on chromosome 15q25.1 that increase the risks of both lung cancer and nicotine dependence and associated smoking behavior. However, there remains debate as to whether the association with lung cancer is direct or is mediated by pathways related to smoking behavior. Here, the authors apply a novel method for mediation analysis, allowing for gene-environment interaction, to a lung cancer case-control study (1992-2004) conducted at… CONTINUE READING
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