Genetic variants of the monocyte chemoattractant protein-1 gene and its receptor CCR2 and risk of coronary artery disease: a meta-analysis.

@article{Wang2011GeneticVO,
  title={Genetic variants of the monocyte chemoattractant protein-1 gene and its receptor CCR2 and risk of coronary artery disease: a meta-analysis.},
  author={Yuyao Wang and Weili Zhang and Shaohua Li and Weihua Song and Jingzhou Chen and Rutai Hui},
  journal={Atherosclerosis},
  year={2011},
  volume={219 1},
  pages={224-30}
}
OBJECTIVE Monocyte chemoattractant protein-1 (MCP-1) and its receptor chemokine (C-C motif) receptor 2 (CCR2) are implicated in promoting atherosclerosis. Many studies have searched the association between variants of the MCP-1 gene or CCR2 gene and risk of coronary artery disease (CAD), but the results are inconsistent. METHODS We conducted a meta-analysis of 20 publications including 24 studies on 2 genetic variants [A-2518G in the MCP-1 and V64I in the CCR2] published before January 2011… CONTINUE READING