Genetic variants of hepatitis B virus and their clinical relevance.

  title={Genetic variants of hepatitis B virus and their clinical relevance.},
  author={Thomas F Baumert and Heidi Barth and H. E. Blum},
  journal={Minerva gastroenterologica e dietologica},
  volume={51 1},
Infection with hepatitis B virus (HBV) leads to a wide spectrum of clinical presentations ranging from an asymptomatic carrier state to self-limited acute or fulminant hepatitis to chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma (HCC). Infection with HBV is one of the most common viral diseases affecting man. Both viral factors as well as the host immune response have been implicated in the pathogenesis and clinical outcome of HBV infection. Evidence has been… CONTINUE READING