Genetic variants of alpha1-antitrypsin.

  title={Genetic variants of alpha1-antitrypsin.},
  author={Parveen Salahuddin},
  journal={Current protein & peptide science},
  volume={11 2},
Alpha1-antitrypsin (alpha1-AT) is a 52 kDa sialoglycoprotein. The function of alpha1-antitrypsin is to protect the lower respiratory tract of lungs from proteolytic degradation by neutrophil elastase. Severe genetic deficiency of alpha1-AT is associated with early onset emphysema and liver diseases. alpha1-AT also exhibits anti-inflammatory activities independent of its protease inhibitor function. There are over 90 genetic variants of human alpha1-antitrypsin. These variants occur due to amino… CONTINUE READING


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