Genetic variants of IL-13 signalling and human asthma and atopy.

  title={Genetic variants of IL-13 signalling and human asthma and atopy.},
  author={Andrea Heinzmann and Xin Qing Mao and Mina Akaiwa and R T Kreomer and P S Gao and Koichi Ohshima and R Umeshita and Yoke Abe and Sandra Braun and Tetsuji Yamashita and Mark H. Roberts and Rie Sugimoto and Kazuhiko Arima and Yojirou Arinobu and Bao-feng Yu and Susanne Kruse and Tadao Enomoto and Yoshio Dake and Mitsuru Kawai and Shin-ichiro Shimazu and Shin Sasaki and Chaker N. Adra and Masanori Kitaichi and Hiromasa Inoue and Kohei Yamauchi and Nobukazu Tomichi and Fumihiko Kurimoto and Naotaka Hamasaki and Julian M. Hopkin and Kenji Izuhara and Taro Shirakawa and Klaus A. Deichmann},
  journal={Human molecular genetics},
  volume={9 4},
Asthma and atopy show epidemiological association and are biologically linked by T-helper type 2 (T(h)2) cytokine-driven inflammatory mechanisms. IL-4 operates through the IL-4 receptor (IL-4R, a heterodimer of IL-4Ralpha and either gammac or IL-13Ralpha1) and IL-13 operates through IL-13R (a heterodimer of IL-4Ralpha and IL-13Ralpha1) to promote IgE synthesis and IgE-based mucosal inflammation which typify atopy. Recent animal model data suggest that IL-13 is a central cytokine in promoting… CONTINUE READING
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