Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

  title={Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.},
  author={Yasuhiro Uno and Akinori Matsushita and Naoki Osada and Shotaro Uehara and Sakae Kohara and Ryoichi Nagata and Koichiro Fukuzaki and Masahiro Utoh and Norie Murayama and Hiroshi Yamazaki},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={38 2},
Cynomolgus and rhesus macaques are frequently used in preclinical trials due to their close evolutionary relationships to humans. We conducted an initial screening for genetic variants in cynomolgus and rhesus macaque genes orthologous to human CYP3A4 and CYP3A5. Genetic screening of 78 Indochinese and Indonesian cynomolgus macaques and 34 Chinese rhesus macaques revealed a combined total of 42 CYP3A4 genetic variants, including 12 nonsynonymous variants, and 34 CYP3A5 genetic variants… CONTINUE READING