Genetic variants of C2 muscle cells that are defective in synthesis of the alpha-subunit of the acetylcholine receptor

@article{Black1987GeneticVO,
  title={Genetic variants of C2 muscle cells that are defective in synthesis of the alpha-subunit of the acetylcholine receptor},
  author={Robert Black and Daniel Goldman and Susan Hochschwender and J. C. Lindstrom and Zach W. Hall},
  journal={The Journal of Cell Biology},
  year={1987},
  volume={105},
  pages={1329 - 1336}
}
We have analyzed two genetic variants of C2 muscle cells that have reduced levels of binding activity for alpha-bungarotoxin and have found that both synthesize only low levels of the alpha-subunit of the acetylcholine receptor. In both variants the uptake of 22Na in response to carbachol is diminished in proportion to the reduction in toxin-binding activity. In addition, the kinetic and sedimentation properties of the residual toxin-binding activity in both is indistinguishable from that seen… CONTINUE READING
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