Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism.

@article{Katzov2004GeneticVO,
  title={Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism.},
  author={Hagit Katzov and Katy Chalmers and Juni Palmgren and Niels Andreasen and B Johansson and Nigel J. Cairns and Margaret Gatz and G. K. Wilcock and Seth Love and Nancy L Pedersen and Anthony J. Brookes and K Blennow and Patrick Gavin Kehoe and Jonathan A. Prince},
  journal={Human mutation},
  year={2004},
  volume={23 4},
  pages={358-67}
}
Linkage studies have provided evidence that one or more loci on chromosome 9q influence Alzheimer disease (AD). The gene encoding the ATP-binding cassette A1 transporter (ABCA1) resides within proximity of previously identified linkage peaks and represents a plausible biological candidate for AD due to its central role in cellular lipid homeostasis. Several single nucleotide polymorphisms (SNPs) spanning ABCA1 have been genotyped and haplotype-based association analyses performed in four… CONTINUE READING