Genetic variants in the ITGB6 gene is associated with the risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy

@article{Yi2015GeneticVI,
  title={Genetic variants in the ITGB6 gene is associated with the risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy},
  author={Minxiao Yi and Yang Tang and Bo Liu and Qianxia Li and Xiao Zhou and Shiying Yu and Shengling Fu and Yixin Cai and Xianglin Yuan},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={3469-3477}
}
The αvβ6 integrin is a cell surface adhesion molecule that plays critical roles in the injury and inflammation processes. We hypothesized that polymorphisms in αvβ6 integrin genes (ITGAV and ITGB6) might be associated with the risk of radiation pneumonitis (RP) in lung cancer patients treated with thoracic radiation. We genotyped three potentially functional αvβ6 integrin single-nucleotide polymorphisms (rs1839123 and rs4129787 in ITGAV, and rs4665162 in ITGB6) and found that the genotypes of… CONTINUE READING