Genetic variants in the IL1A gene region contribute to intestinal‐type gastric carcinoma susceptibility in European populations

  title={Genetic variants in the IL1A gene region contribute to intestinal‐type gastric carcinoma susceptibility in European populations},
  author={Cec{\'i}lia Dur{\~a}es and Xavier Mu{\~n}oz and Catalina Bonet Bonet and Nadia Garc{\'i}a and Adoraci{\~o}n Vencesl{\'a} and F{\'a}tima Carneiro and B{\'a}rbara Peleteiro and Nuno Lunet and Henrique Barros and Björn Lindkvist and Marie‐Christine Boutron‐Ruault and H. B(as). Bueno-de-Mesquita and Cosmeri Rizzato and Antonia Trichopoulou and Elisabete Weiderpass and A Naccarati and Ruth C. Travis and Anne Tj{\o}nneland and Aurelio Barricarte Gurrea and Mattias Johansson and Elio Riboli and C{\'e}u Figueiredo and Carlos Alberto Gonz{\'a}lez and Gabriel Capell{\'a} and Jos{\'e} Carlos Machado and N{\'u}ria Sala},
  journal={International Journal of Cancer},
The most studied genetic susceptibility factors involved in gastric carcinoma (GC) risk are polymorphisms in the inflammation‐linked genes interleukin 1 (IL1) B and IL1RN. Despite the evidence pointing to the IL1 region, definite functional variants reproducible across populations of different genetic background have not been discovered so far. A high density linkage disequilibrium (LD) map of the IL1 gene cluster was established using HapMap to identify haplotype tagSNPs. Eighty‐seven SNPs… Expand
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