Genetic variants in the IL1A gene region contribute to intestinal‐type gastric carcinoma susceptibility in European populations

@article{Dures2014GeneticVI,
  title={Genetic variants in the IL1A gene region contribute to intestinal‐type gastric carcinoma susceptibility in European populations},
  author={Cec{\'i}lia Dur{\~a}es and Xavier Mu{\~n}oz and Catalina Bonet Bonet and Nadia Garc{\'i}a and Adoraci{\~o}n Vencesl{\'a} and F{\'a}tima Carneiro and B{\'a}rbara Peleteiro and Nuno Lunet and Henrique Barros and Björn Lindkvist and Marie‐Christine Boutron‐Ruault and H. B(as). Bueno-de-Mesquita and Cosmeri Rizzato and Antonia Trichopoulou and Elisabete Weiderpass and A Naccarati and Ruth C. Travis and Anne Tj{\o}nneland and Aurelio Barricarte Gurrea and Mattias Johansson and Elio Riboli and C{\'e}u Figueiredo and Carlos Alberto Gonz{\'a}lez and Gabriel Capell{\'a} and Jos{\'e} Carlos Machado and N{\'u}ria Sala},
  journal={International Journal of Cancer},
  year={2014},
  volume={135}
}
The most studied genetic susceptibility factors involved in gastric carcinoma (GC) risk are polymorphisms in the inflammation‐linked genes interleukin 1 (IL1) B and IL1RN. Despite the evidence pointing to the IL1 region, definite functional variants reproducible across populations of different genetic background have not been discovered so far. A high density linkage disequilibrium (LD) map of the IL1 gene cluster was established using HapMap to identify haplotype tagSNPs. Eighty‐seven SNPs… Expand
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References

SHOWING 1-10 OF 59 REFERENCES
Gastric Cancer Susceptibility Is Not Linked to Pro-and Anti-Inflammatory Cytokine Gene Polymorphisms in Whites: A Nationwide Multicenter Study in Spain
TLDR
The results show that, at least in some white populations, the contribution of the cytokine gene polymorphisms evaluated in this study to GC susceptibility may be less relevant than previously reported. Expand
Ovarian cancer risk associated with inherited inflammation-related variants.
TLDR
Genotyped SNPs in a large panel of inflammatory genes in 930 epithelial ovarian cancer cases and 1,037 controls revealed association with SNPs rs17561 and rs4848300 in the interleukin gene IL1A which varied by histologic subtype, but not with the most common serous subtype. Expand
Prostate stem‐cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: Results from the EPIC‐EURGAST study
TLDR
The association between variation in the promoter region of PSCA and GC risk in Caucasians is confirmed and also indicates that the rs2294008 variant is a similar risk factor for both the diffuse and intestinal‐types of GC. Expand
Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analyses.
TLDR
The results indicate the importance of stratification by anatomic site, histologic type, H. pylori infection, and country of origin, and study quality considerations, which can also affect results. Expand
Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).
TLDR
This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC. Expand
Association of IL‐1 polymorphisms and IL‐1 serum levels with susceptibility to nasopharyngeal carcinoma
TLDR
The rs3783553 (TTCA insertion or deletion) polymorphism of the IL‐1A gene was significantly associated with the susceptibility to NPC, and the variant homozygote genotype +/+ was associated with a significantly reduced risk of NPC as compared with the wild homozygotes −/− genotype. Expand
Polymorphisms in Inflammation-related Genes and Risk of Gastric Cancer (Finland)
TLDR
The hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals is not supported. Expand
Association Between Cytokine Gene Polymorphisms and Gastric Precancerous Lesions: Systematic Review and Meta-analysis
TLDR
The IL1RN*22 genotype seems to consistently increase the risk of gastric precancerous lesions, supporting a role for this polymorphism in the early stages of Gastric carcinogenesis. Expand
Multiplex genotyping of 1107 SNPs from 232 candidate genes identified an association between IL1A polymorphism and breast cancer risk.
TLDR
A common genetic variant in IL1A strongly associated with breast cancer risk was identified and identified using multiplex genotyping among Korean women. Expand
Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma.
TLDR
A significant association between the IL-1 polymorphisms and increased risk for tumor development in patients with intestinal-type gastric carcinoma is found and evidence pointing to the existence of a synergistic interaction between theIL-1B and IL- 1RN polymorphisms is found. Expand
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