Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck.

@article{Liu2010GeneticVI,
  title={Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck.},
  author={Zhensheng Liu and Guojun Li and Sheng Wei and Jiangong Niu and A El-naggar and Erich M Sturgis and Qingyi Wei},
  journal={Cancer},
  year={2010},
  volume={116 20},
  pages={4753-60}
}
BACKGROUND Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may alter the processing, transcription, and expression of miRNAs and, thus, may contribute to cancer development. The authors hypothesized that common polymorphisms in pre-miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN). METHODS The authors genotyped 4 common polymorphisms in pre-miRNAs: Homo sapiens miRNA 146a (hsa-mir-146a… CONTINUE READING
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