Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians.

@article{Nan2009GeneticVI,
  title={Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians.},
  author={Hongmei Nan and Peter Kraft and David J. Hunter and Jiali Han},
  journal={International journal of cancer},
  year={2009},
  volume={125 4},
  pages={909-17}
}
Human pigmentation is a polygenic quantitative trait with high heritability. Although a large number of single nucleotide polymorphisms (SNPs) have been identified in pigmentation genes, very few SNPs have been examined in relation to human pigmentary phenotypes and skin cancer risk. We evaluated the associations between 15 SNPs in 8 candidate pigmentation genes (TYR, TYRP1, OCA2, SLC24A5, SLC45A2, POMC, ASIP and ATRN) and both pigmentary phenotypes (hair color, skin color and tanning ability… CONTINUE READING

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