Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.

@article{Gong2015GeneticVI,
  title={Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.},
  author={Zhihong Gong and Song Yao and Gary Robert Zirpoli and Ting-Yuan David Cheng and Michelle R. Roberts and Thaer Khoury and Gregory L. Ciupak and Warren Davis and Karen S. Pawlish and Lina Jandorf and Dana Howard Bovbjerg and Elisa V. Bandera and Christine B. Ambrosone},
  journal={International journal of cancer},
  year={2015},
  volume={137 3},
  pages={666-77}
}
Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We conducted a comprehensive analysis of SNPs in eleven genes involved in one-carbon metabolism and risk of breast cancer in 1,275 European-American (EA) and 1,299 African-American (AA… CONTINUE READING
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