Genetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals.

@article{Barral2014GeneticVI,
  title={Genetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals.},
  author={Sandra M Barral and Christiane Reitz and Scott A. Small and Richard P. Mayeux},
  journal={Neurobiology of aging},
  year={2014},
  volume={35 12},
  pages={2881.e7-2881.e10}
}
The molecular pathways underlying age-related memory changes remain unclear. There is a substantial genetic contribution to memory performance through life span. A recent study has implicated RbAp48, which mediates its effect on age-related memory decline by interacting with cyclic adenosine monophosphate responsive element binding protein (CREB)1 binding protein and influencing this histone acetylation pathway. To validate these findings, we tested whether genetic variants in RbAp48, CREB1… CONTINUE READING
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