Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

@article{Ross2009GeneticVI,
  title={Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy},
  author={C. Ross and Hagit Katzov-Eckert and M. Dub{\'e} and B. Brooks and S. Rassekh and A. Barhdadi and Yassamin Feroz-Zada and H. Visscher and A. Brown and M. Rieder and P. Rogers and M. Phillips and B. Carleton and M. Hayden},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={1345-1349}
}
  • C. Ross, Hagit Katzov-Eckert, +11 authors M. Hayden
  • Published 2009
  • Biology, Medicine
  • Nature Genetics
  • Cisplatin is a widely used and effective chemotherapeutic agent, although its use is restricted by the high incidence of irreversible ototoxicity associated with it. In children, cisplatin ototoxicity is a serious and pervasive problem, affecting more than 60% of those receiving cisplatin and compromising language and cognitive development. Candidate gene studies have previously reported associations of cisplatin ototoxicity with genetic variants in the genes encoding glutathione S-transferases… CONTINUE READING
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