Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

@article{Ross2009GeneticVI,
  title={Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy},
  author={Colin J D Ross and Hagit Katzov-Eckert and Marie-Pierre Dub{\'e} and Beth Brooks and S Rod Rassekh and Amina Barhdadi and Yassamin Feroz-Zada and Henk Visscher and Andrew M. K. Brown and Michael J Rieder and Paul C. Rogers and Michael S. Phillips and Bruce C. Carleton and Michael R. Hayden},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={1345-1349}
}
Cisplatin is a widely used and effective chemotherapeutic agent, although its use is restricted by the high incidence of irreversible ototoxicity associated with it. In children, cisplatin ototoxicity is a serious and pervasive problem, affecting more than 60% of those receiving cisplatin and compromising language and cognitive development. Candidate gene studies have previously reported associations of cisplatin ototoxicity with genetic variants in the genes encoding glutathione S-transferases… 
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Genetic variation of cisplatin-induced ototoxicity in non-cranial-irradiated pediatric patients using a candidate gene approach: The International PanCareLIFE Study
TLDR
A polygenic model is proposed, which takes into account multiple interacting genes of the cisplatin pathway that together confer an increased risk of ototoxicity.
Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: Results of the European PanCareLIFE cohort study.
Genetic variation in Otos is associated with cisplatin-induced ototoxicity.
TLDR
A potentially protective role for the variant G alleles of SNPs rs77124181 and rs2291767 in Otos against the development of cisplatin-induced ototoxicity is indicated.
Economic impact of a genetic test for cisplatin-induced ototoxicity
TLDR
It is estimated that administering this genetic test to every pediatric cancer patient for whom cisplatin is first-line therapy could potentially avoid an average of $71 168 in societal costs per tested patient, which translates into a potential present value savings of over $2.4 million annually in British Columbia and over $19.6 million in Canada.
TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity
TLDR
An association between the ACYP2 polymorphism and cisplatin-induced ototoxicity, but not with the TPMT and COMT is shown.
Chemotherapy refractory testicular germ cell tumor is associated with a variant in Armadillo Repeat gene deleted in Velco-Cardio-Facial syndrome (ARVCF)
TLDR
This is the first study to suggest that germline genetic variants of ARVCF may affect TGCT outcome and the result of this study is hypothesis generating and should be validated in future studies.
Genetic Determinants of Ototoxicity During and After Childhood Cancer Treatment: Protocol for the PanCareLIFE Study
TLDR
Genetic factors identified as part of this pan-European project, PanCareLIFE, may contribute to future risk prediction models that can be incorporated in future clinical trials of platinum-based therapies for cancer and may help with the development of prevention strategies.
Cisplatin ototoxicity in children: risk factors and its relationship with polymorphisms of DNA repair genes ERCC1, ERCC2, and XRCC1
TLDR
It was found that there was no relationship between DNA repair gene polymorphisms and hearing toxicity of cisplatin, and the polymorphism in DNA repair genes was studied using primer and probes in Light Cycler device after DNA isolation was carried out with PCR technique.
Analysis of genetic and non genetic risk factors for cisplatin ototoxicity in pediatric patients.
Investigating the genetic basis of cisplatin-induced ototoxicity in adult South African patients
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