Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma

@article{Jiang2013GeneticVI,
  title={Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma},
  author={Deke Jiang and Jielin Sun and Guangwen Cao and Yao Liu and Dongxin Lin and Yu-Zhen Gao and Weihua Ren and Xi-Dai Long and Hongxing Zhang and Xiaopin Ma and Zhenyao Wang and Weiwei Jiang and Tao-yang Chen and Yong-feng Gao and Liangdan Sun and Jirong Long and Hui-Xing Huang and Dan Wang and Hongjie Yu and Pengyin Zhang and Li-Sha Tang and Bo Peng and Hao Cai and Ting Liu and Ping Zhou and Fang Liu and Xiao-ling Lin and Sha Tao and Bo Wan and He-xi Ge Sai-Yin and Lunxiu Qin and Jianhua Yin and Li Liu and Chengqing Wu and Yan-zhen Pei and Yuan Zhou and Yun Zhai and Pei-xin Lu and Aihua Tan and Xianbo Zuo and Jia Fan and Jiang Chang and Xiaoli Gu and Neng-Jin Wang and Yingying Li and Yin-kun Liu and Kan Zhai and Hongwei Zhang and Zhibin Hu and Jun Liu and Qing Yi and Yong-Bing Xiang and Rong Shi and Qiang Ding and Wei Zheng and Xiao-Ou Shu and Zengnan Mo and Yin Yao Shugart and Xue-Jun Zhang and Gangqiao Zhou and Hongbing Shen and S. Lilly Zheng and Jianfeng Xu and Long Yu},
  journal={Nature Genetics},
  year={2013},
  volume={45},
  pages={72-75}
}
To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, we carried out a genome-wide association study (GWAS) in 2,514 chronic HBV carriers (1,161 HCC cases and 1,353 controls) followed by a 2-stage validation among 6 independent populations of chronic HBV carriers (4,319 cases and 4,966 controls). The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, Pmeta… Expand
Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci of STAT4 and HLA-DQ in a Korean population.
  • L. Kim, H. Cheong, +9 authors Y. Kim
  • Biology, Medicine
  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2015
TLDR
Although the genetic effects of two HCC susceptibility loci were found to exert susceptibility effects on the risk of CHB in a Korean population, the decreased mRNA expression in HCC subjects might provide a clue to understanding their role in the progression to HCC. Expand
Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis
TLDR
It is suggested that genetic variants associated with HBV-related hepatocarcinogenesis may already play an important role in the progression from CHB to LC. Expand
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A genome-wide association study among Chinese populations to identify novel genetic loci contributing to susceptibility to HBV-related HCC highlights a novel locus at 7q21.13 conferring both susceptibility and prognosis to HCC, and suggests the CDK14 gene to be the functional target of the 7q 21.13 locus. Expand
Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma
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A genome-wide association study including 473 Japanese HBV-positive HCC patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated withHBV-derived HCC in Japanese and other East Asian populations finds that additional genetic factors may exist in the HLA class I region. Expand
Variants Identified by Hepatocellular Carcinoma and Chronic Hepatitis B Virus Infection Susceptibility GWAS Associated with Survival in HBV-Related Hepatocellular Carcinoma
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The results suggest that HCC or CHB susceptibility loci might also affect the prognosis of patients with HBV-related HCC. Expand
Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma
TLDR
It is found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian, and further validation of the results in larger populations and different ethnicities are required. Expand
Genetic polymorphism of HLA-DQ confers susceptibility to hepatitis B virus-related hepatocellular carcinoma: a case-control study in Han population in China
TLDR
This study suggested that HLA-DQ loci (rs9275572) were associated with HBV-related HCC as a protective factor in Han Chinese. Expand
Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study
TLDR
The HBV genotype, the mutations and the HLA-DQ/DR SNPs may serve as biomarkers for the surveillance of HBV persistent carriers and their interactions with host variants are evaluated. Expand
Quantitative assessment of common genetic variations in HLA-DP with hepatitis B virus infection, clearance and hepatocellular carcinoma development
TLDR
A meta-analysis of 62,050 subjects from 29 case-control studies found that genetic variants in the HLA-DP locus are strongly associated with reduced HBV infection and increased the likelihood of spontaneous viral clearance. Expand
Quantitative assessment of HLA-DQ gene polymorphisms with the development of hepatitis B virus infection, clearance, liver cirrhosis, and hepatocellular carcinoma
TLDR
The data revealed that the HLA-DQ alleles rs2856718-G, rs7453920-A and rs9275319-G were significantly associated with decreased risk of HBV infection and HBV natural clearance, but rs9272105-A increased the risk ofHBV-related HCC. Expand
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