Genetic variants in ICAM1, PPARGC1A and MTHFR are potentially associated with different phenotypes of diabetic retinopathy.

@article{Simes2014GeneticVI,
  title={Genetic variants in ICAM1, PPARGC1A and MTHFR are potentially associated with different phenotypes of diabetic retinopathy.},
  author={Maria Jos{\'e} Sim{\~o}es and Conceiç{\~a}o Lobo and Conceiç{\~a}o Egas and Sandrina Nunes and Susanna Carmona and Miguel {\^A}ngelo Silva da Costa and Tania P. S. Duarte and Luisa Ribeiro and Carlos Faro and Jos{\'e} G. Cunha-vaz},
  journal={Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde},
  year={2014},
  volume={232 3},
  pages={156-62}
}
PURPOSE To explore phenotype-genotype correlations that may contribute to a better understanding of diabetic retinopathy (DR). PROCEDURES An exploratory association study was performed to identify genetic variants associated with non-proliferative DR (NPDR) in 307 type 2 diabetic patients who were previously stratified into 3 different phenotypes of NPDR progression. The 307 patients were genotyped for 174 single nucleotide polymorphisms of 11 candidate genes (ACE, AGER, AKR1B1, ICAM1, MTHFR… CONTINUE READING

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