Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia.

@article{Liao2009GeneticVI,
  title={Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia.},
  author={S Y Liao and Shih-Hua Lin and Chan-Min Liu and Ming H. Hsieh and Tai J u Hwang and Shi Kai Liu and S-C Guo and H-G Hwu and Wei J Chen},
  journal={Genes, brain, and behavior},
  year={2009},
  volume={8 2},
  pages={228-37}
}
This study examined the relations of genetic variants in catechol-O-methyltransferase (COMT) gene, including rs737865 in intron 1, rs4680 in exon 4 (Val158Met) and downstream rs165599, to schizophrenia and its related neurocognitive functions in families of patients with schizophrenia. Totally, 680 individuals from 166 simplex (166 affected members and 354 nonpsychotic first-degree relatives) and 46 multiplex families (85 affected members and 75 nonpsychotic first-degree relatives) were… CONTINUE READING