Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study

@inproceedings{Perera2013GeneticVA,
  title={Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study},
  author={Minoli A Perera and Larisa H. Cavallari and Nita A. Limdi and Eric R. Gamazon and Anuar Konkashbaev and Roxana Daneshjou and A. V. Pluzhnikov and Dana C. Crawford and Jelai Wang and Nianjun Liu and Nicholas P. Tatonetti and St{\'e}phane Bourgeois and Harumi Takahashi and Yukiko Bradford and Benjamin M Burkley and Robert J Desnick and Jonathan L. Halperin and Sherief Ibrahim Khalifa and Taimour Y Langaee and Steven A Lubitz and Edith A Nutescu and Matthew Oetjens and Mohamed Hossam A. Shahin and Shitalben Radheshyambhai Patel and Hersh Sagreiya and Matthew Tector and Karen E. Weck and Mark J. Rieder and Stuart A Scott and Alan Hsueh-Bing Wu and James K. Burmester and Mia Wadelius and Panagiotis Deloukas and Michael Johann Wagner and Taisei Mushiroda and Michiaki Kubo and Dan M. Roden and Nancy J. Cox and Russ B. Altman and Teri E. Klein and Yusuke Nakamura and Julie A. Johnson},
  booktitle={The Lancet},
  year={2013}
}
BACKGROUND VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans. METHODS We did a genome-wide association study of discovery and replication cohorts. Samples from African-American adults (aged ≥18 years) who were taking a stable maintenance dose of warfarin… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-9 OF 9 REFERENCES

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Simone Rost, Andreas Fregin, +10 authors Johannes Oldenburg
  • Nature
  • 2004

PLINK . [ Software ] 2009 Oct . 10 , 2009 [ cited 2009

S Purcell

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