Genetic variants associated with predisposition to prostate cancer and potential clinical implications.

@article{Goh2012GeneticVA,
  title={Genetic variants associated with predisposition to prostate cancer and potential clinical implications.},
  author={Chee Leng Goh and Fredrick R Schumacher and Douglas Easton and Kenneth Muir and Brian Henderson and Zsofia Kote-Jarai and Rosalind A. Eeles},
  journal={Journal of internal medicine},
  year={2012},
  volume={271 4},
  pages={353-65}
}
Prostate cancer is the commonest cancer in the developed world. There is an inherited component to this disease as shown in familial and twin studies. However, the discovery of these variants has been difficult. The emergence of genome-wide association studies has led to the identification of over 46 susceptibility loci. Their clinical utility to predict risk, response to treatment, or treatment toxicity, remains undefined. Large consortia are needed to achieve adequate statistical power to… CONTINUE READING
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