Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.

@article{Noth2013GeneticVA,
  title={Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.},
  author={Imre Noth and Yingze Zhang and S Ma and Carlos Flores and Mathew D. Barber and Yong Huang and Steven M. Broderick and Michael S. Wade and Pirro G Hysi and Joseph Scuirba and Thomas J. Richards and Brenda M. Juan-Guardela and Rekha Vij and Meilan Han and Fernando J Martinez and Karl Kossen and Scott D. Seiwert and Jason D. Christie and Dan L. Nicolae and Naftali Kaminski and Joe G. N. Garcia},
  journal={The Lancet. Respiratory medicine},
  year={2013},
  volume={1 4},
  pages={309-317}
}
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a devastating disease that probably involves several genetic loci. Several rare genetic variants and one common single nucleotide polymorphism (SNP) of MUC5B have been associated with the disease. Our aim was to identify additional common variants associated with susceptibility and ultimately mortality in IPF. METHODS First, we did a three-stage genome-wide association study (GWAS): stage one was a discovery GWAS; and stages two and three were… CONTINUE READING
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