Genetic variants associated with cisplatin-induced hearing loss.

  title={Genetic variants associated with cisplatin-induced hearing loss.},
  author={Kusala A Pussegoda},
  journal={Clinical genetics},
  volume={78 1},
Although there are many factors that contribute to a patient’s response to therapy, genetic factors account for a significant proportion of variability in drug response and are estimated to play a role in at least half of all adverse drug reactions (ADRs) (1). Genetic variability in drug metabolizing enzymes and transport systems involved in absorption, distribution, excretion and metabolism may lead to drug-induced toxicity causing, life-long disability or even death (2). This is of particular… CONTINUE READING