Genetic variants and animal models in <ce:italic>SNCA</ce:italic> and Parkinson disease

@article{Deng2014GeneticVA,
  title={Genetic variants and animal models in <ce:italic>SNCA</ce:italic> and Parkinson disease},
  author={Hao Deng and Lamei Yuan},
  journal={Ageing Research Reviews},
  year={2014},
  volume={15},
  pages={161-176}
}
Parkinson disease (PD; MIM 168600) is the second most common progressive neurodegenerative disorder characterized by a variety of motor and non-motor features. To date, at least 20 loci and 15 disease-causing genes for parkinsonism have been identified. Among them, the α-synuclein (SNCA) gene was associated with PARK1/PARK4. Point mutations, duplications and triplications in the SNCA gene cause a rare dominant form of PD in familial and sporadic PD cases. The α-synuclein protein, a member of… CONTINUE READING
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