Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests

@article{Elmer1998GeneticVI,
  title={Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests},
  author={Gregory I. Elmer and Jeanne O. Pieper and Ş. Neguş and J. H. Woods},
  journal={Pain},
  year={1998},
  volume={75},
  pages={129-140}
}
The perceived intensity of a painful stimulus is determined in part by the stimulus intensity and environmental conditions. The purpose of this study was to determine the influence of genetic factors in nociception and its contribution to the potency of morphine to produce antinociception. Eight inbred strains of mice were tested across a range of stimulus intensities in thermal (hot plate) and chemical irritant (acetic acid) nociceptive tests. Stimulus intensities in the thermal test included… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 46 CITATIONS

The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics.

  • The Journal of pharmacology and experimental therapeutics
  • 2003
VIEW 5 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

Sex differences in supraspinal morphine analgesia are dependent on genotype.

  • The Journal of pharmacology and experimental therapeutics
  • 1999
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…