Genetic variability of measles virus in acute and persistent infections.

  title={Genetic variability of measles virus in acute and persistent infections.},
  author={Mirjam K{\"u}hne and David W. Brown and Li Jin},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  volume={6 4},
RNA viruses have high nucleotide substitution rates, and therefore the potential to mutate rapidly. In the case of vaccine preventable RNA viruses, this may potentially lead to emergence of vaccine escape mutants. The WHO has targeted measles virus (MV) for elimination in many regions, and its genetic variability is monitored to estimate appearance of such mutants. Phylogenetic analysis of partial N or H genes of 230 MV strains circulating in the UK over a 10-year period was performed… CONTINUE READING