Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.

@article{LpezLabrador2004GeneticVO,
  title={Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.},
  author={F. Xavier L{\'o}pez-Labrador and X He and Marina Berenguer and R. C. Cheung and Fernando Gonz{\'a}lez-Candelas and Teresa Lyn Wright and Harry B Greenberg},
  journal={Journal of medical virology},
  year={2004},
  volume={72 4},
  pages={575-85}
}
Hepatitis C virus (HCV) variation in specific T-cell epitopes may represent a mechanism of viral persistence in chronic infection. We examined the HCV non-structural protein 3 (NS3), including the immunologically relevant epitopes HCV NS3-2 KLVALGINAV (human leukocyte antigen [HLA]-A2-restricted) and HCV NS3-1391 LIFCHSKKK (HLA-A3-restricted), in 22 HLA-A2+ patients with chronic infection. Significant amino acid variation was found in HCV NS3-2 epitope sequences when compared to the HCV-1… CONTINUE READING