Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function

@article{Stingl2013GeneticVO,
  title={Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function},
  author={J. Stingl and J. Brockm{\"o}ller and R. Viviani},
  journal={Molecular Psychiatry},
  year={2013},
  volume={18},
  pages={273-287}
}
  • J. Stingl, J. Brockmöller, R. Viviani
  • Published 2013
  • Medicine
  • Molecular Psychiatry
  • Polymorphic drug-metabolizing enzymes (DMEs) are responsible for the metabolism of the majority of psychotropic drugs. By explaining a large portion of variability in individual drug metabolism, pharmacogenetics offers a diagnostic tool in the burgeoning era of personalized medicine. This review updates existing evidence on the influence of pharmacogenetic variants on drug exposure and discusses the rationale for genetic testing in the clinical context. Dose adjustments based on pharmacogenetic… CONTINUE READING
    Significance of CYP2D Polymorphism

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