Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice.

@article{Brewer1999GeneticVI,
  title={Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice.},
  author={Joanne P. Brewer and Alison B. Kisselgof and Thomas R. Martin},
  journal={American journal of respiratory and critical care medicine},
  year={1999},
  volume={160 4},
  pages={1150-6}
}
Wide differences among inbred mouse strains in susceptibility to develop components of asthmalike pulmonary changes would provide insights into the nature of the relationships among those components and set the stage for genetic approaches to their etiology. We therefore examined pulmonary pathophysiological and serum immunoglobulin (Ig)E responses in mice of 12 inbred strains sensitized intraperitoneally with ovalbumin (OVA) and repeatedly exposed to aerosolized OVA. One day after the last OVA… CONTINUE READING

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