Genetic variability in IGF-1 and IGFBP-3 and body size in early life

@inproceedings{Poole2012GeneticVI,
  title={Genetic variability in IGF-1 and IGFBP-3 and body size in early life},
  author={Elizabeth M Poole and Shelley S Tworoger and Susan E. Hankinson and Heather J. Baer},
  booktitle={BMC public health},
  year={2012}
}
BACKGROUND Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previous studies have examined the role of IGF-1 and IGFBP-3 genetic variation in relation to adult height and body size, but few studies have examined associations with birthweight and childhood size. METHODS We examined whether htSNPs in IGF-1 and the IGFBP-1/IGFBP-3 gene region… CONTINUE READING