Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels.

@article{Zhang2007GeneticVA,
  title={Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels.},
  author={Yuan-yuan Zhang and Lucia Gottardo and Wojciech Mlynarski and Winfred Frazier and David N Nolan and Jill Duffy and Maria Cristina Marescotti and Ernest V. Gervino and Michael T. Johnstone and Christos Socrates Mantzoros and Angelo Avogaro and Alessandro Doria},
  journal={Atherosclerosis},
  year={2007},
  volume={191 1},
  pages={121-7}
}
OBJECTIVE Cellular and animal studies suggest that leptin has proinflammatory and prothrombotic effects that could link increased adipose mass directly to atherogenesis. To investigate this hypothesis, we examined the effect of genetic variability at the leptin receptor (LEPR) locus on the plasma levels of fibrinogen and CRP--two markers of inflammation and susceptibility to atherosclerosis. METHODS AND RESULTS Linkage disequilibrium analysis of 71 single-nucleotide polymorphisms (SNPs… CONTINUE READING