Genetic vaccines protect against Sin Nombre hantavirus challenge in the deer mouse (Peromyscus maniculatus).

@article{Bharadwaj2002GeneticVP,
  title={Genetic vaccines protect against Sin Nombre hantavirus challenge in the deer mouse (Peromyscus maniculatus).},
  author={Mausumi Bharadwaj and Katy Mirowsky and Chunyan Ye and Jason William Botten and Barbara J. Masten and Joyce S. R. Yee and C Richard Lyons and Brian Hjelle},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 7},
  pages={1745-51}
}
We used a deer mouse (Peromyscus maniculatus) infection model to test the protective efficacy of genetic vaccine candidates for Sin Nombre (SN) virus that were known to provoke immunological responses in BALB/c mice (Bharadwaj et al., Vaccine 17, 2836-2843, 1999 ). Protective epitopes were localized in each of four overlapping cDNA fragments that encoded portions of the SN virus G1 glycoprotein antigen; the nucleocapsid gene also was protective. The protective efficacy of glycoprotein gene… CONTINUE READING