Genetic transfer of a nonpeptide antagonist binding site to a previously unresponsive angiotensin receptor.

@article{Ji1995GeneticTO,
  title={Genetic transfer of a nonpeptide antagonist binding site to a previously unresponsive angiotensin receptor.},
  author={H Ji and Wenhua Zheng and Yuan-wei Zhang and Kevin J. Catt and Kathryn Sandberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 20},
  pages={9240-4}
}
Mutational analysis based on the pharmacological differences between mammalian and amphibian angiotensin II receptors (AT receptors) previously identified 7 aa residues located in transmembrane domains (TMs) III (Val-108), IV (Ala-163), V (Pro-192, Thr-198), VI (Ser-252), and VII (Leu-300, Phe-301) of the rat AT receptor type 1b (rAT1b receptor) that significantly influenced binding of the nonpeptide antagonist Losartan. Further studies have shown that an additional 6 residues in the rAT1b… CONTINUE READING

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