Genetic toxicology of bleomycin.

  title={Genetic toxicology of bleomycin.},
  author={Baldev K. Vig and Robert T. Lewis},
  journal={Mutation research},
  volume={55 2},
Bleomycin (BLM), an antibiotic obtained from Streptomyces verticillus, is of significance as an antineoplastic agent. The compound is actually the mixture of some 200 related forms which differ from each other in the amine moiety. The drug, at low concentrations, can cause elimination of bases, particularly thymine. This causes strand breakage of DNA and inhibition of cell growth. The influence of BLM on cell growth may be unrelated to the effects on DNA. In general, mitotically dividing cells… CONTINUE READING


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