Genetic testing in hereditary colorectal cancer: indications and procedures

@article{Terdiman1999GeneticTI,
  title={Genetic testing in hereditary colorectal cancer: indications and procedures},
  author={Jonathan P. Terdiman and Peggy G. Conrad and Marvin H. Sleisenger},
  journal={American Journal of Gastroenterology},
  year={1999},
  volume={94},
  pages={2344-2356}
}
Approximately 25% of colorectal cancers occur in younger individuals or those with a personal or family history of the disease, suggesting a heritable susceptibility. The minority of these cases are accounted for by one of the well-described hereditary colorectal cancer syndromes, familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). The recent identification and cloning of the genes responsible for FAP and HNPCC, along with other colon cancer… CONTINUE READING
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Somatic instability 2354

  • R Gryfe, N Di Nicola, S Gallinger
  • Terdiman et al. AJG – Vol. 94, No
  • 1999
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