Genetic testing for male infertility: a postulated role for mutations in sperm nuclear matrix attachment regions.

@article{Kramer1997GeneticTF,
  title={Genetic testing for male infertility: a postulated role for mutations in sperm nuclear matrix attachment regions.},
  author={J. A. Kramer and Shouzou Zhang and Yuval Yaron and Y Zhao and Stephen A. Krawetz},
  journal={Genetic testing},
  year={1997},
  volume={1 2},
  pages={
          125-9
        }
}
Numerous reports have suggested that disturbances in nuclear condensation may result in male infertility. This notion has been supported by the observation of infertile individuals with a decrease or absence of the male sperm-specific chromatin packaging protamine proteins. To date, no correlation between the absence of protamine proteins and a mutation within the coding regions of the protamine genes has been documented. To address this issue, PCR-based mutation scanning analysis has been… CONTINUE READING

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